Department of Environmental Health, Center for Environmental Genetics, Cancer Institute, College of Medicine, University of Cincinnati, 3223 Eden Avenue, Kettering Laboratory Complex, Cincinnati, OH 45267, USA.Cincinnati Veterans Affairs Medical Center, 3200 Vine Street, Cincinnati, OH 45220, USA.
The mainstay targets for hormonal prostate cancer (PCa) therapies are based on negating androgen action. Recent epidemiologic and experimental data have pinpointed the key roles of estrogens in PCa development and progression. Racial and geographic differences, as well as age-associated changes, in estrogen synthesis and metabolism contribute significantly to the etiology. This article summarizes how different estrogens/antiestrogens/estrogen mimics contribute to prostate carcinogenesis, the roles of the different mediators of estrogen in the process, and the potentials of new estrogenic/antiestrogenic compounds for prevention and treatment of PCa.
Ho SM, Lee MT, Lam HM, Leung YK. Are you the author?
Reference: Endocrinol Metab Clin North Am. 2011 Sep;40(3):591-614.