Second-line therapy for castrate-resistant prostate cancer: A literature review - Abstract

Department of Medical Oncology, Concord Repatriation General Hospital University of Sydney, Sydney, NSW, Australia.

Department of Medical Oncology, Prince of Wales Hospital University of New South Wales; Sydney Adventist Hospital, Sydney, NSW, Australia.



Despite a survival benefit in the first-line treatment of castrate-resistant prostate cancer (CRPC) with docetaxel, the prognosis remains limited. There are increasing options available for patients with CRPC in the second-line setting, but there is currently little consensus regarding the optimal treatment. There have been numerous phase II and retrospective studies examining second-line options in CRPC, including retreatment with docetaxel, mitoxantrone, cyclophosphamide and carboplatin, which can be associated with meaningful responses in a significant minority of patients. In 2010 three randomized trials were published or presented which demonstrated a survival benefit in the second-line setting. These included cabazitaxel compared with mitoxantrone, sipuleucel-T (immunotherapy) and abiraterone acetate versus placebo. Ongoing research in the second-line setting of CRPC to optimize treatment options, with the objectives of survival prolongation, improvement in quality of life and pain management, is still needed.

Written by:
Kao SC, Hovey E, Marx G.   Are you the author?

Reference: Asia Pac J Clin Oncol. 2011 Sep;7(3):212-23.
doi: 10.1111/j.1743-7563.2011.01421.x

PubMed Abstract
PMID: 21884433 Prostate Cancer Section



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