Post-translational modification of the androgen receptor - Abstract

Department of Microbiology University of Virginia, Charlottesville, Virginia, USA.

UVA Cancer Center University of Virginia, Charlottesville, Virginia, USA.



Regulation of the androgen receptor (AR) by its cognate ligand is well established, but how post-translational modification modulates AR activity is only emerging. The AR is subject to modification by phosphorylation, acetylation, methylation, SUMOylation, and ubiquitination. As several of the enzymes that modify the AR are altered in prostate cancer, defining the context and physiological effects of these modifications could provide insight into mechanisms that underpin human disease. Here, we review how post-translational modification contributes to AR function as a transcription factor with particular emphasis on phosphorylation and dephosphorylation mechanisms.

Written by:
Gioeli D, Paschal BM.   Are you the author?

Reference: Mol Cell Endocrinol. 2011 Jul 24. Epub ahead of print.
doi: 10.1016/j.mce.2011.07.004

PubMed Abstract
PMID: 21820033 Prostate Cancer Section