Accuracy of high resolution (1.5 tesla) pelvic phased array magnetic resonance imaging (MRI) in staging prostate cancer in candidates for radical prostatectomy: Results from a prospective study - Abstract

Academic Department of Radiology, La Pitié-Salpétriére, Groupe Hospitalo-Universitaire EST, Assistance-Publique Hôpitaux de Paris.

Faculté de Médecine Pierre et Marie Curie, University Paris VI, Paris, France.



To evaluate the role of pelvic phased array MRI in staging prostate cancer (CaP).

We prospectively collected data over 12 months on CaP patients who underwent preoperative MR imaging with a pelvic phased array before radical prostatectomy. MR images were analyzed prospectively by 2 radiologists. MR imaging findings were then correlated with pathologic findings.

Overall, 101 patients were included with a mean PSA level of 8 (range 1.8-30). Reader 1 (AUC 0.895, 95% CI 0.791-0.999) had a higher performance than reader 2 (AUC 0.687, 95% CI, 0.555-0.819) and than DRE (AUC 0.728, 95% CI, 0.599-0.857) in discriminating T2 from T3 CaP (P = 0.01). The κ-index of inter-observer agreement was 0.56. A model that combines MRI findings, DRE, PSA, and Gleason score was the most competitive for staging (AUC 0.895, 95% CI, 0.791-0.999). For the multivariate analysis, 3 criteria were significantly associated with extracapsular extension: asymmetry of the neuro-vascular bundles (P = 0.001), asymmetric enhancement of neurovascular bundles (P = 0.02), and bulging of the capsule (P = 0.0003).

Pelvic phased array MRI presented satisfying results in its ability to adequately stage CaP and notably in detecting the extracapsular extension of tumors. It is likely to provide reliable information but rather in the hands of an experienced radiologist.

Written by:
Renard-Penna R, Rouprêt M, Comperat E, Ayed A, Coudert M, Mozer P, Xylinas E, Bitker MO, Grenier P.   Are you the author?

Reference: Urol Oncol. 2011 Jul 18. Epub ahead of print.
doi: 10.1016/j.urolonc.2011.02.017

PubMed Abstract
PMID: 21775172 Prostate Cancer Section