No association of type-2 diabetes risk variants and prostate cancer risk: The Multiethnic Cohort and PAGE - Abstract

Preventive Medicine, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Harlyne Tower, 1450 Biggy St., Room 1516, Los Angeles, CA, 90089, United States.


Epidemiologic studies have found evidence of an inverse association between diabetes status and prostate cancer risk. We explored the hypothesis that common genetic variation may explain, in part, the inverse association between diabetes and prostate cancer.

We tested 17 diabetes risk variants for association with prostate cancer risk in a prostate cancer case-control study of 2,746 cases and 3,317 controls from five racial-ethnic groups in the Multiethnic Cohort.

After adjustment for multiple testing none of the alleles were statistically significantly associated with prostate cancer risk. Aggregate scores that sum the risk alleles were also not significantly associated with risk.

We did not find evidence of association of this set of diabetes risk alleles with prostate cancer.

Resequencing and fine-mapping of the GWAS-identified loci for diabetes and prostate cancer is necessary to understand any genetic contribution for the inverse association between these common diseases.

Written by:
Waters KM, Wilkens LR, Monroe KR, Stram DO, Kolonel LN, Henderson BE, Le Marchand L, Haiman CA.   Are you the author?

Reference: Cancer Epidemiol Biomarkers Prev. 2011 Jul 12. Epub ahead of print.
doi: 10.1158/1055-9965.EPI-11-0019

PubMed Abstract
PMID: 21750171 Prostate Cancer Section