Martini-Clinic, Prostate Cancer Center Hamburg-Eppendorf, Hamburg, Germany.Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Canada.
Existing population-based reports on complication rates after minimally invasive radical prostatectomy (MIRP) did not address temporal trends.
To examine contemporary temporal trends in perioperative MIRP outcomes.
Between 2001 and 2007, 4387 patients undergoing MIRP were identified using the Nationwide Inpatient Sample.
To examine the rates and trends of intraoperative and postoperative complications, transfusion rates, length of stay in excess of the median, and in-hospital mortality. We tested the effect of the late (2006-2007) versus the early (2001-2005) study period on all outcomes using multivariable logistic regression models controlled for clustering among hospitals.
Intraoperative and postoperative complications decreased from 7.0% to 0.8% (p< 0.001) and from 28.5% to 8.7% (p< 0.001), respectively. Transfusion rates decreased from 3.5% to 2.1% (p=0.3). Hospital length of stay >2 d decreased from 56% to 15% (p< 0.001). In multivariable analyses, intraoperative (odds ratio [OR]: 0.41; p=0.002) and postoperative (OR: 0.65; p=0.007) complications were less frequent in the late versus the early study period. Late study period patients were less likely to stay >2 d than early study period patients (OR: 0.34; p > 0.001). Limitations of these findings include the lack of adjustment for several patient variables including disease characteristics, surgeon variables including surgeon caseload, and the restriction to in-hospital events.
Our analyses demonstrate that in-hospital complication rates and length of stay after MIRP decreased over time. This implies that temporal differences specific to complication rates after MIRP must be considered when comparisons are made with other radical prostatectomy techniques.
Schmitges J, Trinh QD, Abdollah F, Sun M, Bianchi M, Budäus L, Zorn K, Perotte P, Schlomm T, Haese A, Montorsi F, Menon M, Graefen M, Karakiewicz PI. Are you the author?
Reference: Eur Urol. 2011 Jun 25. Epub ahead of print.