Office of Oncology Drug Products, Office of New Drugs, and the Office of Biostatistics, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD.
The use of 5α-reductase inhibitors for prevention of prostate cancer continues to be widely discussed within the scientific and medical communities.(1) Much of this discussion has been fueled by the findings of two large randomized, placebo-controlled trials - the Prostate Cancer Prevention Trial (PCPT) with finasteride and the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) trial (ClinicalTrials.gov number, NCT00056407).(2),(3) Together, these trials showed an overall relative reduction of 23 to 25% in prostate-cancer diagnoses, a seemingly significant benefit from drugs aimed at preventing one of the most common cancers in men. However, the observed reduction resulted from a . . .
Theoret MR, Ning YM, Zhang JJ, Justice R, Keegan P, Pazdur R. Are you the author?
Reference: N Engl J Med. 2011 Jun 15. Epub ahead of print.