Antiangiogenic agents and endothelin antagonists in advanced castration resistant prostate cancer - Abstract

Medical Oncology Department, University Hospital La Paz, Madrid, Spain.


Despite multiple advances in prostate cancer therapy, treatment options for castration resistant disease are very limited. While data from recent studies are encouraging, there is no drug that has significantly improved results of standard chemotherapy. Some of the most consistent results are provided by antiangiogenic agents, showing high response rates and manageable toxicity. We describe some of the main therapeutic angiogenesis inhibitors in metastatic castration resistant prostate cancer. These agents include vascular endothelial growth factor inhibitors, tyrosine kinase inhibitors, antiangiogenic and inmunomodulatory agents and endothelin receptor antagonists.

Written by:
Merino M, Pinto A, González R, Espinosa E.   Are you the author?

Reference: Eur J Cancer. 2011 May 18. Epub ahead of print.
doi: 10.1016/j.ejca.2011.04.020

PubMed Abstract
PMID: 21600762 Prostate Cancer Section