Histopathological correlation of (11)C-choline PET scans for target volume definition in radical prostate radiotherapy - Abstract

Radiation Oncology Centre, Austin Health, Victoria, Australia.

University of Melbourne, Victoria, Australia.



To evaluate the accuracy of (11)C-choline PET scans in defining dominant intraprostatic lesions (DILs) for radiotherapy target volume definition.

Eight men with prostate cancer who had (11)C-choline PET scans prior to radical prostatectomy were studied. Several methods were used to contour the DIL on the PET scans: visual, PET Edge, Region Grow, absolute standardised uptake value (SUV) thresholds and percentage of maximum SUV thresholds. Prostatectomy specimens were sliced in the transverse plane and DILs were delineated on these by a pathologist. These were then compared with the PET scans. The accuracy of correlation was assessed by the Dice similarity coefficient (DSC) and the Youden index.

The contouring method resulting in both the highest DSC and the highest Youden index was 60% of the maximum SUV (SUV(60%)), with values of 0.64 and 0.51, respectively. However SUV(60%) was not statistically significantly better than all of the other methods by either measure.

Although not statistically significant, SUV(60%) resulted in the best correlation between (11)C-choline PET and pathology amongst all the methods studied. The degree of correlation shown here is consistent with previous studies that have justified using imaging for DIL radiotherapy target volume definition.

Written by:
Chang JH, Joon DL, Lee ST, Gong SJ, Scott AM, Davis ID, Clouston D, Bolton D, Hamilton CS, Khoo V.   Are you the author?

Reference: Radiother Oncol. 2011 May 18. Epub ahead of print.
doi: 10.1016/j.radonc.2011.03.012

PubMed Abstract
PMID: 21600669

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