Pathological findings after radical prostatectomy in men eligible for active surveillance (French trial SURACAP): Is the misclassification rate acceptable? - Abstract

Service d'urologie, Inserm Unit 955 EQ7, hôpital Henri-Mondor, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France.


To analyze pathological data of the radical prostatectomy specimen in patients operated for clinically-localized prostate cancer and who meet strict criteria for active surveillance necessary to be included in the French trial SURACAP.

The data of patients who underwent a radical prostatectomy at our institution between 1998 and 2010 were reviewed. We only included the patients that met the usual criteria for active surveillance: clinical stage T1-2a tumor, PSA ≤ 10ng/mL, biopsy Gleason sum inferior or equal to 6 with no pattern of grade 4 or 5, cancer involvement inferior or equal to two biopsy cores, inferior to 3mm of malignant tissue in each positive biopsy core. From them, only those who were diagnosed from a second line biopsies cores were included for further analysis.

Overall, 48 patient who met the "SURACAP" criteria had a laparoscopic radical prostatectomy at out institution. Mean age was 65.4 years. The mean preoperative PSA was 6.1ng/mL. Clinical stage of the tumor was T1c in 95% of patients and T2a in 5%. Biopsy Gleason score was 6(3+3) in 100%. Pathological analysis of the surgical specimen showed that 19% of patients had a seminal vesicle invasion or an extracapsular extension. The Gleason score of the pathological specimen was 6 (3 +3) in 57% of patients, 7 (3 +4) in 38% and 8 (4 +4) in 5% of patients. The Gleason score upgrading was 43% of patients.

In our experience, 19% of patients who meet the criteria for active surveillance show an extracapsular extension or a seminal vesicle invasion on pathological analysis. Active surveillance is still under evaluation.

Article in French.

Written by:
Xylinas E, Durand X, Campeggi A, Ploussard G, Allory Y, Vordos D, Hoznek A, De La Taille A, Abbou CC, Salomon L.   Are you the author?

Reference: Prog Urol. 2011 Apr;21(4):264-269.
doi: 10.1016/j.purol.2010.09.021

PubMed Abstract
PMID: 21482401 Prostate Cancer Section