A total of 2,205 consecutive men who underwent radical prostatectomy for clinically localized prostate cancer, with a mean follow-up of 6.8 years, were included. Patients were stratified by the year of surgery (1992-1995 versus 1996-1998 versus 1999-2001 versus 2002-2005), and competing risk analyses were performed considering non-prostate cancer deaths as events and prostate cancer deaths as competing events. The survival curves were compared.
There was an increase in mean patient age during the study period (63.8-64.0-64.6-64.9 years). There was a trend towards decreasing competing mortality. Simultaneously, there was also a non-significant trend towards decreasing prostate cancer mortality (5-year rates: 3.5 %-2.8 %-1.4 %-1.1 %). These data suggest that despite increasing life expectancy in some geographic areas, with competing mortality halved during the study period, the effect did not reach significance. They do not recommend changing patient selection criteria at this time. The results are confounded by a decrease in prostate cancer mortality, probably due to earlier detection.
Presented by Michael Fröhner, MD, et al. at the 26th Annual European Association of Urology (EAU) Congress - March 18 - 21, 2011 - Austria Centre Vienna, Vienna, Austria