Influence of publication of US and European Prostate Cancer Screening Trials on PSA testing practices - Abstract

Health Services Research and Development Center of Excellence, VA Puget Sound Health Care System, 1100 Olive Way, Ste 1400, Seattle, WA 98101.

In 2009, results from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial indicated no difference in mortality between the screening and the control groups (rate ratio = 1.13, 95% confidence interval = 0.75 to 1.70), whereas those from the European Randomized study of Screening for Prostate Cancer trial indicated a 20% reduction in mortality among the screening group (rate ratio = 0.80, 95% confidence interval = 0.65 to 0.98). In this study, we examined whether prostate-specific antigen (PSA) testing has changed following these publications. The primary outcome measure was the proportion of men seen at least once in a primary care or urology clinic between August 1, 2004, and March 31, 2010, who received a PSA test. Following the publications, PSA use declined slightly-by 3.0 percentage points and 2.7 percentage points among men aged 40-54 and 55-74 years, respectively. PSA testing among men older than 75 years initially declined slightly following the recommendations by the US Preventive Services Task Force in 2008 and continued to decline after the trial publications.

Written by:
Zeliadt SB, Hoffman RM, Etzioni R, Gore JL, Kessler LG, Lin DW.   Are you the author?

Reference: J Natl Cancer Inst. 2011 Mar 16;103(6):520-3.
doi: 10.1093/jnci/djr007

PubMed Abstract
PMID: 21357307 Prostate Cancer Section