Evaluation of semi-quantitative dynamic contrast-enhanced MRI parameters for prostate cancer in correlation to whole-mount histopathology - Abstract

Department of Radiation Oncology, University Hospitals Leuven, Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium.

To evaluate the use of semi-quantitative dynamic contrast-enhanced MRI (DCE-MRI) parameters for the detection of prostatic carcinoma in correlation to whole-mount histopathology.

Fifty-three patients with biopsy-proven prostate cancer were examined by DCE-MRI at 1.5-T. Cancerous and benign prostatic tissue regions of interest were delineated based on the histopathology of whole-mount sections and several semi-quantitative parameters were calculated: time to peak (TTP), maximal contrast enhancement (Cpeak), speed of contrast uptake (Wash-in) and clearance rate of the contrast agent (Wash-out). The area under the ROC curve was determined for each parameter.

Within individual patients, a consistently higher Cpeak and faster Wash-in were present in cancerous compared to benign prostatic tissue. Both the TTP and the Wash-out occurred more rapidly in tumour tissue than in normal prostatic tissue. Despite a considerable inter-patient overlap of parameter values between tumour and normal prostatic tissue, area under the ROC curve analysis demonstrated that the Wash-in was a good discriminator for cancer and benign tissue (AUC 0.82). Combination of the Wash-in and the Wash-out proved to be even more accurate (AUC 0.87) to discriminate between cancerous and benign prostatic regions.

The Wash-in is a useful parameter for prostate cancer detection by DCE-MRI.

Written by:
Isebaert S, De Keyzer F, Haustermans K, Lerut E, Roskams T, Roebben I, Van Poppel H, Joniau S, Oyen R.   Are you the author?

Reference: Eur J Radiol. 2011 Feb 22. Epub ahead of print.
doi: 10.1016/j.ejrad.2011.01.107

PubMed Abstract
PMID: 21349667

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