Results of high dose-rate brachytherapy boost before 2D or 3D external beam irradiation for prostate cancer - Abstract

Institute of Cancer Arnaldo Vieira de Carvalho, University of São Paulo, Brazil. Radiology Department of Hospital das Clínicas of Faculty of Medicine, University of São Paulo, Brazil.

To evaluate biochemical control and treatment related toxicity of patients with localized adenocarcinoma of the prostate treated with high dose-rate brachytherapy (HDRB) combined with conventional 2D or 3D-conformal external beam irradiation (EBI).

Four-hundred and three patients treated between December 2000 and March 2004. HDRB was delivered with three fractions of 5.5-7Gy with a single implant, followed by 45Gy delivered with 2D or 3D conformal EBI.

The median follow-up was 48.4months. Biochemical failure (BF) occurred in 9.6% according to both ASTRO and Phoenix consensus criteria. Mean time to relapse was 13 and 26months, respectively. The 5-year BF free survival using the ASTRO criteria was 94.3%, 86.9% and 86.6% for the low, intermediate and high risk groups, respectively; using Phoenix criteria, 92.4%, 88.0% and 85.3%, respectively. The only predictive factor of BF in the multivariate analysis by both ASTRO and Phoenix criteria was the presence of prostate nodules detected by digital palpation, and patients younger than 60years presented a higher chance of failure using Phoenix criteria only.

Treatment scheme is feasible and safe with good efficacy.

Written by:
Neviani CB, Miziara MA, de Andrade Carvalho H.   Are you the author?

Reference: Radiother Oncol. 2011 Feb;98(2):169-74.
doi: 10.1016/j.radonc.2011.01.005

PubMed Abstract
PMID: 21296444 Prostate Cancer Section