Next-generation prostate-specific membrane antigen (PSMA) positron emission tomography imaging provides unprecedented accuracy for prostate cancer (PC) detection and can provide detailed disease metrics, which we summarize as a PSMA spatial biomarker (PSMA-SB). Overall survival data confirm that PSMA-SB can differentiate aggressive PC from indolent PC. PSMA-SB maps could be integrated with multiomics data to improve understanding of total-body cancer heterogeneity and phenotype.
European urology. 2024 Oct 19 [Epub ahead of print]
Wolfgang P Fendler, Viktor Grünwald, Ken Herrmann, Boris A Hadaschik
Department of Nuclear Medicine, University of Duisburg-Essen and German Cancer Consortium, University Hospital Essen, Essen, Germany. Electronic address: ., Department of Urology, University of Duisburg-Essen and German Cancer Consortium, University Hospital Essen, Essen, Germany; Department of Medical Oncology, University of Duisburg-Essen and German Cancer Consortium, University Hospital Essen, Essen, Germany., Department of Nuclear Medicine, University of Duisburg-Essen and German Cancer Consortium, University Hospital Essen, Essen, Germany., Department of Urology, University of Duisburg-Essen and German Cancer Consortium, University Hospital Essen, Essen, Germany.