Weekly ultra-hypofractionated radiotherapy in localised prostate cancer.

Moderately hypofractionated radiotherapy regimens or stereotactic body radiotherapy (SBRT) are standard of care for localised prostate cancer. However, some patients are unable or unwilling to travel daily to the radiotherapy department and do not have access to, or are not candidates for, SBRT. For many years, The Royal Marsden Hospital NHS Foundation Trust has offered a weekly ultra-hypofractionated radiotherapy regimen to the prostate (36 Gy in 6 weekly fractions) to patients unable/unwilling to travel daily.

The current study is a retrospective analysis of all patients with non-metastatic localised prostate cancer receiving this treatment schedule from 2010 to 2015.

A total of 140 patients were included in the analysis, of whom 86 % presented with high risk disease, with 31 % having Gleason Grade Group 4 or 5 disease and 48 % T3 disease or higher. All patients received hormone treatment, and there was often a long interval between start of hormone treatment and start of radiotherapy (median of 11 months), with 34 % of all patients having progressed to non-metastatic castrate-resistant disease prior to start of radiotherapy. Median follow-up was 52 months. Median progression-free survival (PFS) and overall survival (OS) for the whole group was 70 months and 72 months, respectively. PFS and OS in patients with hormone-sensitive disease at time of radiotherapy was not reached and 75 months, respectively; and in patients with castrate-resistant disease at time of radiotherapy it was 20 months and 61 months, respectively.

Our data shows that a weekly ultra-hypofractionated radiotherapy regimen for prostate cancer could be an option in those patients for whom daily treatment or SBRT is not an option.

Clinical and translational radiation oncology. 2024 May 26*** epublish ***

Nora Sundahl, Douglas Brand, Chris Parker, David Dearnaley, Alison Tree, Angela Pathmanathan, Yae-Eun Suh, Nicholas Van As, Rosalind Eeles, Vincent Khoo, Robert Huddart, Julia Murray

Urological Oncology Department, Royal Marsden Hospital NHS Foundation Trust, London & Sutton, UK., Radiotherapy and Imaging Division, The Institute of Cancer Research, London & Sutton, UK., Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.