Recruiting African American Prostate Cancer Survivors for a Population-Based Biobank Study.

Prostate cancer (PC) affects African American men disproportionately compared to men of other racial/ethnic groups. To identify biological bases for this health disparity, we sought to create a state-wide biobank of African American PC survivors in Florida.

African American men diagnosed with PC between 2013-2017 and living in Florida at diagnosis were identified through the State of Florida's cancer registry. Individuals were approached via mail and telephone, assessed for eligibility, and asked for informed consent. Chi-square and t-tests were conducted to identify differences between eligible and reachable individuals (i.e., had valid contact information) vs. consented participants.

Of the 5,960 eligible and reachable individuals, 3,904 were eligible and contacted at least once, and 578 consented (overall consent rate=10% [578/5,960]; adjusted consent rate=15% [578/3,904]). Statistically significant (ps<.05) but small differences in demographic and clinical variables were observed. Consented participants were less likely to be older than 64 (35% vs. 41%) and less likely to have received radiotherapy (36% vs. 41%) and hormone therapy (16% vs. 21%), but more likely to have regional PC (13% vs. 11%) and have undergone surgery (44% vs. 39%). Consented participants did not differ from reachable individuals on other demographic and clinical factors (ps>.05).

Recruiting African American PC survivors to biobanking research through a cancer registry is feasible. However, the consent rate was low, and existing challenges limit consent and participation.

Strategies for overcoming barriers to informed consent and increasing participation in biospecimen research are needed to address cancer disparities.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2023 Mar 23 [Epub ahead of print]

Xiaoyin Li, Siddhartha Roy, Jennifer Damonte, Hyun Y Park, Aasha I Hoogland, Kala Jamison, Khaled R Komrokji, Chang Dong Yeo, Youngchul Kim, Jasreman Dhillon, Lisa M Gudenkauf, Laura B Oswald, Heather S L Jim, Kosj Yamoah, Julio M Pow-Sang, Peter A Kanetsky, Clement K Gwede, Jong Y Park, Brian D Gonzalez

Moffitt Cancer Center, Tampa, FL, United States., Penn State College of Medicine, United States., National Cancer Institute, Rockville, MD, United States., Moffitt Cancer Center, Tampa, Florida, United States., Syneos Health (United States), United States., Eunpyeong St. Mary's Hospital, Seoul, Korea (South), Republic of., Moffitt Cancer Center, Tampa, United States., H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, United States., H Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States.