Diabetes and the Prostate: Elevated Fasting Glucose, Insulin Resistance and Higher Levels of Adrenal Steroids in Prostate Cancer.

Although epidemiological studies suggest a lower prostate cancer incidence rate in patients with type 2 diabetes, cancer survival is markedly reduced. Underlying mechanisms that connect the two diseases are still unclear. Potential links between type 2 diabetes and prostate cancer are hallmarks of the metabolic syndrome, such as hyperglycemia and dyslipidemia. Therefore, we explored the systemic metabolism of 103 prostate cancer patients with newly diagnosed and yet untreated prostate cancer compared to 107 healthy controls, who were carefully matched for age and BMI. Here, we report that patients with prostate cancer display higher fasting blood glucose levels and insulin resistance, without changes in insulin secretion. With respect to lipid metabolism, serum triglyceride levels were lower in patients with prostate cancer. In addition, we report increased adrenal steroid biosynthesis in these patients. Our results indicate that higher fasting glucose levels in patients with prostate cancer may be explained at least in part by insulin resistance, due to the enhanced synthesis of adrenal steroids.

Journal of clinical medicine. 2022 Nov 15*** epublish ***

Stefan Zoltán Lutz, Jörg Hennenlotter, Andras Franko, Corinna Dannecker, Louise Fritsche, Konstantinos Kantartzis, Róbert Wagner, Andreas Peter, Norbert Stefan, Andreas Fritsche, Tilman Todenhöfer, Arnulf Stenzl, Hans-Ulrich Häring, Martin Heni

Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich, University of Tübingen, 72074 Tübingen, Germany., Department of Urology, University of Tübingen, 72076 Tübingen, Germany., German Center for Diabetes Research (DZD), 85764 Munich, Germany.

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