PSMA-PET Detection of Unusual Metastases in Castrate-Sensitive Prostate Carcinoma.

Prostate cancer (PCa) is a multifaceted, heterogeneous disease (with 7 molecular subtypes), which can metastasize to common sites, such as bone, lymph nodes, liver, and lungs. However, with PSMA PET imaging, rare sites of metastasis are increasingly discovered. We report 5 cases of unusual metastases in patients with castrate-sensitive PCa: solitary right inguinal nodal metastasis, solitary abdominal wall metastasis, penile shaft metastases, solitary perineum metastasis, and pleural metastases. These cases further support the use of PSMA-PET imaging in PCa monitoring, with the ability to detect solitary, small volume, and rare sites of metastases, which may not be apparent on conventional imaging.

Clinical nuclear medicine. 2022 Oct 27 [Epub ahead of print]

Nathanial Harris, Mun Yee Tan, Michael Ng, David Blakey, Mario Guerrieri, Daryl Lim Joon, Eddie Lau, Farshad Foroudi, Alexander Armstrong, Michael Chao

From the Department of Radiation Oncology, Olivia Newton-John Cancer Wellness and Research Centre, Heidelberg., Department of Radiation Oncology, GenesisCare, Melbourne, Victoria, Australia.

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