Performance of Artificial Intelligence-Aided Diagnosis System for Clinically Significant Prostate Cancer with MRI: A Diagnostic Comparison Study.

The high level of expertise required for accurate interpretation of prostate MRI.

To develop and test an artificial intelligence (AI) system for diagnosis of clinically significant prostate cancer (CsPC) with MRI.


One thousand two hundred thirty patients from derivation cohort between Jan 2012 and Oct 2019, and 169 patients from a publicly available data (U-Net: 423 for training/validation and 49 for test and TrumpeNet: 820 for training/validation and 579 for test).

3.0T/scanners, T2 -weighted imaging (T2 WI), diffusion-weighted imaging, and apparent diffusion coefficient map.

Close-loop AI system was trained with an Unet for prostate segmentation and a TrumpetNet for CsPC detection. Performance of AI was tested in 410 internal and 169 external sets against 24 radiologists categorizing into junior, general and subspecialist group. Gleason score >6 was identified as CsPC at pathology.

Area under the receiver operating characteristic curve (AUC-ROC); Delong test; Meta-regression I2 analysis.

In average, for internal test, AI had lower AUC-ROC than subspecialists (0.85 vs. 0.92, P < 0.05), and was comparable to junior (0.84, P = 0.76) and general group (0.86, P = 0.35). For external test, both AI (0.86) and subspecialist (0.86) had higher AUC than junior (0.80, P < 0.05) and general reader (0.83, P < 0.05). In individual, it revealed moderate diagnostic heterogeneity in 24 readers (Mantel-Haenszel I2  = 56.8%, P < 0.01), and AI outperformed 54.2% (13/24) of readers in summary ROC analysis. In multivariate test, Gleason score, zonal location, PI-RADS score and lesion size significantly impacted the accuracy of AI; while effect of data source, MR device and parameter settings on AI performance is insignificant (P > 0.05).

Our AI system can match and to some case exceed clinicians for the diagnosis of CsPC with prostate MRI.


Journal of magnetic resonance imaging : JMRI. 2022 Oct 12 [Epub ahead of print]

Ke-Wen Jiang, Yang Song, Ying Hou, Rui Zhi, Jing Zhang, Mei-Ling Bao, Hai Li, Xu Yan, Wei Xi, Cheng-Xiu Zhang, Ye-Feng Yao, Guang Yang, Yu-Dong Zhang

Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China., Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, People's Republic of China., Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China., MR Scientific Marketing, Siemens Healthcare, Shanghai, People's Republic of China.

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