Advanced prostate cancer (aPC) in Black men was reported to present with aggressive features and to be associated with poor prognosis. Herein, we compared the cell-free DNA (cfDNA) genomic landscape of aPC in Black vs White men. Patients (pts) with aPC from 6 academic institutions and available cfDNA comprehensive genomic profiling (CGP) were included. Association between mutated genes and race was evaluated using Barnard's test and a Probabilistic Graphical Model (PGM) machine learning approach. Analysis included 743 aPC pts (217 Black, 526 White) with available cfDNA CGP. The frequency of alterations in the androgen receptor gene was significantly higher in Black vs White men (55.3% vs 35% respectively, P < .001). Additionally, alterations in EGFR, MYC, FGFR1, and CTNNB1 were present at higher frequencies in Black men. PGM analysis and Barnard's test were concordant. Findings from the largest cohort of Black men with aPC undergoing cfDNA CGP may guide further drug development in these men.
The oncologist. 2022 Aug 29 [Epub ahead of print]
Raquel Zimmerman, Mehmet A Bilen, Elisabeth I Heath, Lakshminarayanan Nandagopal, Umang Swami, Adam Kessel, Ellen Jaeger, Sergiusz Wesolowski, Edgar J Hernanadez, Jonathan Chipman, Alleda Mack, Deepak Ravindranathan, Benjamin L Maughan, Roberto Nussenzveig, Mark Yandell, Manish Kohli, Michael B Lilly, A Oliver Sartor, Neeraj Agarwal, Pedro C Barata
University of Utah School of Medicine, Salt Lake City, UT, USA., Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA., University of Alabama at Birmingham, Birmingham, AL, USA., Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Deming Department of Medicine, Section of Hematology/Oncology, Tulane University Medical School, New Orleans, LA, USA., Department of Human Genetics, University of Utah, Salt Lake City, UT, USA., Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA., Medical University of South Carolina Hollings Cancer Center, Charleston, SC, USA.