Trials in the Key of G: Building Level 1 Evidence on the Real-world Effectiveness of Prostate Biomarkers.

A number of genomic classifiers are available to aid in shared decision-making for men with localized prostate cancer; however, there is no high-level evidence assessing their clinical utility. The two randomized controlled trials in this report prospectively evaluate the use of gene expression classifier testing at the time of cancer diagnosis and after surgical treatment.

European urology focus. 2022 Aug 10 [Epub ahead of print]

Linda A Okoth, Anna C Harris, Udit Singhal, Michael L Cher, Daniel E Spratt, Todd M Morgan

Department of Urology, University of Michigan, Ann Arbor, MI, USA., Department of Urology, University of Michigan, Ann Arbor, MI, USA; Department of Urology, Mayo Clinic, Rochester, MN, USA., Department of Urology, Wayne State University, Detroit, MI, USA., University Hospitals Seidman Cancer Center, Case Western Reserve, Cleveland, OH, USA., Department of Urology, University of Michigan, Ann Arbor, MI, USA. Electronic address: .

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