Comparative results of focal-cryoablation and stereotactic body radiotherapy in the treatment of unilateral, low-to-intermediate-risk prostate cancer.

The purpose of this study is to compare oncologic and functional outcomes of men with unilateral, localized PCa treated with stereotactic body radiotherapy (SBRT) versus focal cryoablation (FC).

Patients from our IRB-approved PCa database who underwent FC or SBRT and were eligible for both treatments were included. Patients with less than 1 year of follow-up or prior PCa treatment were excluded. The primary outcome was treatment failure, defined as salvage treatment or a Gleason group (GG) of ≥ 2 on post-treatment biopsy. Biochemical recurrence (BCR) was evaluated with Phoenix. Functional outcomes were based on EPIC surveys. Complications were categorized with the CTCAE 5.0. Outcomes were compared using descriptive statistics, univariate analyses, and Kaplan-Meier curve for failure-free survival (FFS) and BCR-free survival. P < 0.05 was significant.

68 FC and 51 SBRT patients with a median age of 68 years (48-86) and a median follow-up time of 84 (70-101) months were included in this analysis. There was no difference in tumor risk (p = 0.47), GG (p = 0.20), or PSA (p = 0.70) among the two cohorts at baseline. At 7-year follow-up, no difference in FFS was found between the two cohorts (p = 0.70); however, significantly more FC patients had BCR (p < 0.001). At 48 months, no differences existed in urinary or bowel function; however, SBRT patients had significantly worse sexual function (p = 0.032).

FC and SBRT are associated with similar oncologic and functional outcomes 7-year post-treatment. These results underscore the utility of FC and SBRT for the management of unilateral low-to-intermediate-risk PCa.

International urology and nephrology. 2022 Jul 21 [Epub ahead of print]

Ashley Monaco, Jessica Sommer, Chinyere Okpara, Jonathan W Lischalk, Jonathan Haas, Anthony Corcoran, Aaron Katz

New York Institute of Technology College of Osteopathic Medicine, 101 Northern Boulevard, Old Westbury, NY, 11568, USA. ., Department of Urology, New York University Langone, Hospital-Long Island, 1300 Franklin Ave, Mineola, NY, 11530, USA., Biostatistics Core, Division of Health Services Research, New York University Langone, Hospital-Long Island, 259 1st St, Mineola, NY, 11501, USA., Department of Radiation Oncology, New York University Langone, Hospital-Long Island, 259 1st St., Mineola, NY, 11501, USA.

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