Incidence, Mortality, and Trends of Prostate Cancer in Mexico from 2000 to 2019: Results from the Global Burden of Disease Study 2019.

In 2019, the Global Burden of Disease (GBD) estimated that prostate cancer (PC) was the 16th most common cause of death globally in males. In Mexico, PC epidemiology has been studied by a number of metrics and over various periods, although without including the most up-to-date estimates. Herein, we describe and compare the burdens and trends of PC in Mexico and its 32 states from 2000 to 2019. For this study, we extracted online available data from the GBD 2019 to estimate the crude and age-standardized rates (ASR per 100,000 people) of the incidence and mortality of PC. In Mexico, PC caused 27.1 thousand (95% uncertainty intervals, 20.6-36.0 thousand) incident cases and 9.2 thousand (7.7-12.7 thousand) deaths in males of all ages in 2019. Among the states, Sinaloa had the greatest ASR of incidence, and Guerrero had the highest mortality. The burden of PC showed an increasing trend, although the magnitude of change differed between metrics and locations. We found both an increasing national trend and subnational variation in the burden of PC. Our results confirm the need for updated and timely estimates to design effective diagnostic and treatment campaigns in locations where the burden of PC is the highest.

Cancers. 2022 Jun 29*** epublish ***

Saul A Beltran-Ontiveros, Martha A Fernandez-Galindo, Jose M Moreno-Ortiz, Jose A Contreras-Gutierrez, Jesus Madueña-Molina, Eliakym Arambula-Meraz, Emir Leal-Leon, Delia M Becerril-Camacho, Veronica J Picos-Cardenas, Carla Angulo-Rojo, Diana Z Velazquez, Francisco Jimenez-Trejo, Francisco Gallardo-Vera, Daniel Diaz

Posgrado en Ciencias Biomédicas, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, Culiacán Rosales 80010, Sinaloa, Mexico., Doctorado en Genética Humana, Departamento de Biología Molecular y Genómica, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico., Instituto de Genética Humana "Dr. Enrique Corona Rivera", Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico., Centro de Investigación y Docencia en Ciencias de la Salud, Universidad Autónoma de Sinaloa, Culiacán Rosales 80030, Sinaloa, Mexico., Facultad de Medicina, Universidad Autónoma de Sinaloa, Culiacán Rosales 80246, Sinaloa, Mexico., Laboratorio de Genética y Biología Molecular, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, Culiacán Rosales 80010, Sinaloa, Mexico., Laboratorio de Biomedicina, Universidad Autónoma de Occidente, Unidad Regional Culiacán, Culiacán Rosales 80020, Sinaloa, Mexico., Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados, Gustavo A. Madero 07360, Ciudad de México, Mexico., Laboratorio de Morfología Celular y Tisular, Instituto Nacional de Pediatría, Coyoacán 04530, Ciudad de México, Mexico., Laboratorio de Biología Molecular y Bioseguridad Nivel III, Centro Médico Naval, Coyoacán 04470, Ciudad de México, Mexico., Centro de Ciencias de la Complejidad (C3), Universidad Nacional Autónoma de México, Coyoacán 04510, Ciudad de México, Mexico.

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