Cost-effectiveness analysis of short biparametric magnetic resonance imaging protocol in men at risk of prostate cancer.

To compare the cost-effectiveness of a short biparametric MRI (BP-MRI) with that of contrast-enhanced multiparametric MRI (MP-MRI) for the detection of prostate cancer in men with elevated prostatespecific antigen (PSA) levels.

We compared two diagnostic procedures for detection of prostate cancer (Pca), BP-MRI and MP-MRI, in terms of quality-adjusted life years (QALY), incremental costeffectiveness ratio (ICER) and net monetary benefit (NMB) for a hypothetical cohort of 10,000 patients. We compared two scenarios in which different protocols would be used for the early diagnosis of prostate cancer in relation to PSA values. Scenario 1. BP-MRI/MP-MRI yearly if > 3.0 ng/ml, every 2 years otherwise; Scenario 2. BP-MRI/MP-MRI yearly with age-dependent threshold 3.5 ng/ml (50-59 years), 4.5 ng/ml (60-69 years), 6.5 ng/ml (70-79 years).

BP-MRI was more effective than the comparator in terms of cost (160.10 € vs 249.99€) QALYs (a mean of 9.12 vs 8.46), ICER (a mean of 232.45) and NMB (a mean of 273.439 vs 251.863). BP-MRI was dominant, being more effective and less expensive, with a lower social cost. Scenario 2 was more cost-effective compared to scenario 1.

Our results confirmed the hypothesis that a short bi-parametric MRI protocol represents a cost-efficient procedure, optimizing resources in a policy perspective.

Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica. 2022 Jun 29*** epublish ***

Niccolò Faccioli, Elena Santi, Giovanni Foti, Pierpaolo Curti, Mirko D'Onofrio

Department of Radiology, G.B. Rossi Hospital, UniversitĂ  di Verona, Verona. ., Department of Radiology, Mater Salutis Hospital, Legnago, Verona. ., Department of Radiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar, Verona. ., Department of Radiology, Mater Salutis Hospital, Legnago, Verona. ., Department of Radiology, G.B. Rossi Hospital, UniversitĂ  di Verona, Verona. .

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