Robot-Assisted Surgery vs Robotic Stereotactic Body Radiotherapy in Prostate Cancer: A Cost-Utility Analysis.

Prostate cancer is the most common men cancer in France. Continuous progress in oncology led to develop robot-assisted Radical Prostatectomies (rRP) and robot-assisted stereotactic body radiotherapy (rSBRT). The present study aims at comparing economic and clinical impacts of prostate cancer treatments performed either with rSBRT or rRP in France. A Markov model using TreeAge Pro software was chosen to calculate annual costs; utilities and transition probabilities of localized prostate cancer treatments. Patients were eligible for radiotherapy or surgery and the therapeutic decision was a robot-assisted intervention. Over a 10-year period, rSBRT yielded a significantly higher number of quality-adjusted life years than rRP (8.37 vs 6.85). In France, rSBRT seemed more expensive than rRP (€19,475 vs €18,968, respectively). From a societal perspective, rRP was more cost-saving (incremental cost effectiveness ratio = €332/QALY). The model was sensitive to variations of costs of the initial and recurrence state in one-way sensitivity analyses. Robot-assisted stereotactic body radiotherapy seems more cost-effective than Radical Prostatectomy in terms of QALY despite the slightly higher initial cost due to the use of radiotherapy. It would be interesting to conduct comparative quality of life studies in France over longer periods of time.

Frontiers in oncology. 2022 May 24*** epublish ***

Line Farah, Nicolas Magne, Nicolas Martelli, Sandrine Sotton, Marc Zerbib, Isabelle Borget, Nathaniel Scher, Thierry Guetta, Cyrus Chargari, Olivier Bauduceau, Alain Toledano

Groupe de Recherche et d'accueil en Droit et Economie de la Santé (GRADES) Department, Université Paris Saclay, Châtenay-Malabry, France., Département de radiothérapie, Institut de Cancérologie Lucien Neuwirth, Saint Priest en Jarez, France., Département d'urologie , Service d'urologie, Hôpital Cochin, Paris, France., Département de radiothérapie, Institut de radiothérapie et de radiochirurgie H. Hartmann, Paris, France., Département d'urologie, Clinique Ambroise Paré, Neuilly-sur-Seine, France., Département d'oncologie en radiothérapie, Institut Gustave Roussy, Villejuif, France., Département d'économie de la santé, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.

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