Creation and validation of the harmonized Arabic version of the Expanded Prostate Cancer Index Composite for Clinical Practice (EPIC-CP).

Tocreate and validate a translated Arabic version of the Expanded Prostate Cancer Index Composite for Clinical Practice (EPIC-CP), a validated patient-reported outcome (PRO) widely used for assessing the quality of life in patients with prostate cancer (PCa).

Using the established protocol as defined by the Professional Society for the Health Economics and Outcomes Research (ISPOR) for translating patient care questionnaires, a harmonised translated Arabic version of EPIC-CP was created. The questionnaire was tested in native Arabic speakers from four different Arabic countries (Saudi Arabia, United Arab Emirates, Jordan, and Kuwait). Cronbach's alpha and interclass coefficient correlation (ICC) analyses were used to test the internal consistency and test-retest reliability, respectively. In addition, PCa characteristics were collected for participants.

In total, 168 patients with PCa participated in the study (39 from Saudi Arabia, 23 from United Arab Emirates, 65 from Jordan, and 41 from Kuwait). In all, 52 (31%) participants repeated the questionnaire for test-retest reliability analysis. The median (interquartile range [IQR]) age of patients included in the study was 66 (61-71) years. The median (IQR) PSA level was 9.8 (6-19) ng/mL. Most patients had Grade Group 2 PCa at diagnosis (31%), clinical stage cT1 (42%), managed primarily by urology (79%), and the primary treatment was radical prostatectomy (71%). The total Cronbach's alpha coefficient was 0.84 demonstrating an acceptable internal consistency. The total ICC was also acceptable at 0.64.

The Arabic version of the EPIC-CP is a reliable and valid tool for assessing health-related quality of life for Arabic patients with PCa.

Arab journal of urology. 2021 Nov 28*** epublish ***

Mohannad A Awad, Luke Hallgarth, Ghassan A Barayan, Mohammed Shahait, Ramiz Abu-Hijlih, Ala'a Farkouh, Raed A Azhar, Musab M Alghamdi, Ahmad Bugis, Said Yaiesh, Saad Aldousari, Alaeddin Barham, Mohamed Saed, Ayman Moussa, Waleed Hassen, Shelly Naud, Mark K Plante, Richard Grunert

Department of Surgery, Division of Urology, University of Vermont Medical Center, Burlington, VT, USA., Department of Surgery, King Hussein Cancer Center, Amman, Jordan., Department of Surgery, Division of Urology, King Abdulaziz University, Jeddah, Saudi Arabia., Urology Unit, Department of Surgery, Mubarak Al-Kabeer Hospital, Kuwait, Kuwait., Department of Surgery (Urology Division), Faculty of Medicine, Kuwait University, Kuwait, Kuwait., Urology, Surgical Subspecialties Institute, Cleveland Clinic, Abu Dhabi, United Arab Emirates., Medical Biostatistics, Larner College of Medicine, University of Vermont, Burlington, VT, USA.

email news signup