Foundation Medicine and Collaborators to Share Scientific Advances at AACR22 Reinforcing the Power of Genomic Testing in Precision Cancer Care

New studies demonstrate the ability of Foundation Medicine’s portfolio of tests to improve treatment options for patients, and reinforce the company’s role as an essential partner to researchers

Reno, Nevada (UroToday.com) -- (BUSINESS WIRE)--Foundation Medicine, Inc. announced that the company and its collaborators will present a total of nine studies, including two clinical science symposia presentations and seven poster discussions, at the 2022 American Association for Cancer Research (AACR) Annual Meeting from April 8-13.


Highlights of these presentations include:

  • Two studies spotlighting the concordance between Foundation Medicine’s tissue and blood-based comprehensive genomic profiling (CGP) tests and their complementary value as tools to provide genomic insights to researchers and clinicians.

  • Data on Foundation Medicine’s new algorithm to predict homologous recombination deficiency (HRD) status and identify patients who may be candidates for PARP inhibitors across multiple disease types. Patient identification for PARP inhibitors remains a challenge, but these findings suggest that HRD status, including indel and copy number features, is associated with instability beyond ovarian cancer.

  • A new study leveraging existing data to identify 165 ancestry-associated features across multiple common cancer types. These findings help address the lack of knowledge about ancestry-specific alterations in an effort to overcome barriers to implementing precision medicine, including inequities in genetic testing, targeted treatment and clinical trial design for cancer patients from underserved populations.

"Data being presented at this year’s AACR meeting emphasize our role as an essential partner for our collaborators who are working to identify patients most likely to benefit from new precision therapies," said Priti Hegde, PhD, chief scientific officer at Foundation Medicine. "Our research also highlights how the data derived from our portfolio of tests can shape the future of cancer care and research, including through our novel HRD algorithm."

The following is a list of abstracts that will be presented at the meeting. To access all abstracts being presented at AACR, please visit AACR.org.


Abstract #

Title

Collaborator

Product

Clinical Science Symposia
 

2139

Monday, April 11


Evaluation of tissue- and plasma-derived tumor mutational burden and genomic alterations of interest from the CheckMate 848 clinical trial

Bristol Myers Squibb

Clinical trial assay based on FoundationOne® CDx & Foundation Medicine bTMB Clinical Trial Assay

CT031

Monday, April 11


TALAPRO-1: Talazoparib monotherapy in metastatic castration-resistant prostate cancer (mCRPC) with tumor DNA damage response alterations (DDRm)—Exploration of genomic loss of heterozygosity (gLOH) and potential associations with antitumor activity

Pfizer

Clinical trial assay based on FoundationOne® CDx

Posters
 

57/18

Sunday, April 10


Patients with germline ATM mutations develop clonal hematopoiesis characterized by co-occurrence of multiple somatic ATM alterations
 
FoundationCore®

753 /9

Monday, April 11


Comprehensive genomic profiling (CGP) reveals site-specific enrichment of immunotherapy biomarkers and targetable alterations in non-small cell lung cancer (NSCLC) metastasis
 
FoundationCore®

798 /7

Monday, April 11


Comprehensive genomic profiling of tissue and liquid biopsies reveals the landscape of reversion mutations
 
FoundationCore®

1166/13

Monday, April 11


Leveraging existing data to identify ancestry-associated features across multiple cancer types

Dana Farber Cancer Institute

FoundationCore®

1243/15

Monday, April 11


Identification of aneuploidy biomarkers associated with response to first-line treatment of metastatic pancreatic cancer
 
Foundation Medicine and Flatiron Health’s Clinicogenomic Database

1249 /21

Monday, April 11


Development of a pan-cancer algorithm to predict homologous recombination deficiency and sensitivity to PARPi therapy

University of Minnesota

Foundation Medicine and Flatiron Health’s Clinicogenomic Database & FoundationCore®

3413/19

Tuesday, April 12


Clinical utility of circulating tumor DNA sequencing with a large panel: The experience of Gustave Roussy/ National Center for Precision Medicine (PRISM)

Gustave Roussy Cancer Center

FoundationOne® Liquid CDx


Source: "Foundation Medicine And Collaborators To Share Scientific Advances At AACR22 Reinforcing The Power Of Genomic Testing In Precision Cancer Care | Foundation Medicine". 2022. Foundationmedicine.Com.
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