Application of Artificial Intelligence to Overcome Clinical Information Overload in Urologic Cancer.

To describe the use of artificial intelligence (AI) in medical literature and trial data extraction, and its applications in uro-oncology. This bridging review, which consolidates information from the diverse applications of AI, highlights how AI users can investigate more sophisticated queries than with traditional methods, leading to synthesis of raw data and complex outputs into more actionable and personalized results, particularly in the field of uro-oncology.

Literature and clinical trial searches were performed in PubMed, Dimensions, Embase and Google (1999-2020). The searches focused on the use of AI and its various forms to facilitate literature searches, clinical guidelines development, and clinical trial data extraction in uro-oncology. To illustrate how AI can be applied toaddress questions about optimizing therapeutic decision making and individualizing treatment regimens, the Dimensions-linked information platform was searched for "prostate cancer" keywords (76 publications were identified; 48 were included).

AI offers the promise of transforming raw data and complex outputs into actionable insights. Literature and clinical trial searches can be automated, enabling clinicians to develop and analyze publications expeditiously on complex issues such as therapeutic sequencing and to obtain updates on documents that evolve at the pace and scope of the landscape. An AI-based platform inclusive of 12 trial databases and >100 scientific literature sources enabled the creation of an interactive visualization.

As the literature and clinical trial landscape continues to grow in complexity and with increasing speed, the ability to pull the right information at the right time from different search engines and resources while excluding social media bias becomes more challenging. This review demonstrates that by applying natural language processing and machine learning algorithms, validated and optimized AI leads to a speedier, more personalized, efficient and focused search compared with traditional methods.

BJU international. 2021 Nov 30 [Epub ahead of print]

Arnulf Stenzl, Cora N Sternberg, Jenny Ghith, Lucile Serfass, Bob J A Schijvenaars, Andrea Sboner

Department of Urology, University of Tübingen, Tübingen, Germany., Clinical Director, Englander Institute for Precision Medicine, Professor of Medicine, Weill Cornell Medicine Hematology/Oncology, Sandra and Edward Meyer Cancer Center, New York, NY, USA., Pfizer, Inc, New York, NY, USA., Pfizer Oncology, Paris, France., Digital Science, London, UK., Director of Informatics and Computational Biology, Englander Institute for Precision Medicine; Assistant Professor at the Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.

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