A phase 1 study to assess the safety, pharmacokinetics, and anti-tumor activity of the androgen receptor n-terminal domain inhibitor epi-506 in patients with metastatic castration-resistant prostate cancer.

EPI-506 is the first of a new class of drugs targeting the N-terminal domain (NTD) of the androgen receptor (AR), potentially overcoming known resistance mechanisms to androgen receptor pathway inhibitors (ARPIs) among men with metastatic castration resistant prostate cancer (mCRPC).

Patients with mCRPC who had progressed on prior ARPI were enrolled in this phase 1 open-label, adaptive 3 + 3 dose escalation study. The primary outcome was safety and tolerability of oral EPI-506. Secondary objectives included determination of the maximal tolerated dose (MTD), pharmacokinetic profile, and antitumor efficacy.

28 mCRPC patients were enrolled into 7 dose cohorts of EPI-506 ranging from 80-3600 mg given once daily and 1800 mg given twice daily. Six DLTs occurred in 4 patients; Grade 4 elevated amylase; Grade 3 abdominal pain; Grade 3 elevated ALT and Grade 3 elevated AST; Grade 2 nausea and Grade 1 vomiting which resulted in study drug intake of < 75% of the expected dose during the DLT assessment period. The most common drug-related adverse events included diarrhea, nausea and fatigue. Six patients had a PSA decline not meeting PSA response criteria. The study was terminated prior to reaching the MTD due to poor oral bioavailability.

This phase 1 trial established the safety of EPI-506 and provides proof of concept for targeting the AR NTD. Next generation compounds with improved bioavailability and potency are in clinical development.

Investigational new drugs. 2021 Nov 29 [Epub ahead of print]

Corinne Maurice-Dror, Ronan Le Moigne, Ulka Vaishampayan, Robert B Montgomery, Michael S Gordon, Nan Hyung Hong, Leah DiMascio, Frank Perabo, Kim N Chi

BC Cancer Agency, Vancouver, BC, USA., ESSA Pharmaceuticals, South San Francisco, Vancouve, CA, USA., Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA., University of Washington, Seattle, WA, USA., HonorHealth Research Institute, Scottsdale, AZ, USA., BC Cancer Agency, Vancouver, BC, USA. .

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