Qntifying the impact of SpaceOAR hydrogel on inter-fractional rectal and bladder dose during 0.35 T MR-guided prostate adaptive radiotherapy.

To investigate the impact of rectal spacing on inter-fractional rectal and bladder dose and the need for adaptive planning in prostate cancer patients undergoing SBRT with a 0.35 T MRI-Linac.

We evaluated and compared SBRT plans from prostate cancer patients with and without rectal spacer who underwent treatment on a 0. 35 T MRI-Linac. Each group consisted of 10 randomly selected patients that received prostate SBRT to a total dose of 36.25 Gy in five fractions. Dosimetric differences in planned and delivered rectal and bladder dose and the number of fractions violating OAR constraints were quantified. We also assessed whether adaptive planning was needed to meet constraints for each fraction.

On average, rectal spacing reduced the maximum dose delivered to the rectum by more than 8 Gy (p < 0.001). We also found that D3cc received by the rectum could be 12 Gy higher in patients who did not have rectal spacer (p < 9E-7). In addition, the results show that a rectal spacer can reduce the maximum dose and D15cc to the bladder wall by more than 1 (p < 0.004) and 8 (p < 0.009) Gy, respectively. Our study also shows that using a rectal spacer could reduce the necessity for adaptive planning. The incidence of dose constraint violation was observed in almost 91% of the fractions in patients without the rectal spacer and 52% in patients with implanted spacer.

Inter-fractional changes in rectal and bladder dose were quantified in patients who underwent SBRT with/without rectal SpaceOAR hydrogel. Rectal spacer does not eliminate the need for adaptive planning but reduces its necessity.

Journal of applied clinical medical physics. 2021 Aug 02 [Epub ahead of print]

Reza Farjam, Sean S Mahase, Shu Ling Chen, Madeline Coonce, Ryan T Pennell, Ryan Fecteau, Bilal Chughtai, J Keith Dewyngaert, Josephine Kang, Silvia Ch Formenti, Himanshu Nagar

Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA., Department of Urology, Weill Cornell Medical College, New York, NY, USA.

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