Prospective assessment of two-gene urinary test with multiparametric magnetic resonance imaging of the prostate for men undergoing primary prostate biopsy.

To evaluate the diagnostic accuracy of SelectMDx and its association with multiparametric magnetic resonance (mpMRI) in predicting prostate cancer (PCa) and clinically significant PCa (csPCa) on prostate biopsies among men scheduled for initial prostate biopsy.

In this single-center prospective study, 52 men scheduled for initial prostate biopsy, based on elevated total PSA level (> 3 ng/ml) or abnormal digital rectal examination, were consecutively included. All subjects underwent SelectMDx, PSA determination and mpMRI.

SelectMDx score was positive in 94.1 and 100% of PCa and csPCa, respectively, and in only 8.6% of negative cases at biopsy. The probability for a csPCa at the SelectMDx score was significantly (p = 0.002) higher in csPCa (median value 52.0%) than in all PCa (median value 30.0%). SelectMDx showed slightly lower sensitivity (94.1 versus 100.0%) but higher specificity (91.4%) than total PSA (17.1%), and the same sensitivity but higher specificity than mpMRI (80.0%) in predicting PCa at biopsy. The association of SelectMDx plus mpMRI rather than PSA density (PSAD) plus mpMRI showed higher specificity (both 91.4%) compared to the association of PSA plus mpMRI (85.7%). In terms of csPCa predictive value, SelectMDx showed higher specificity (73.3%) than PSA (13.3%) and mpMRI (64.4%); as for the association of SelectMDx plus mpMRI (75.6%) versus PSA plus mpMRI (68.9%), the association of PSAD plus mpMRI showed the highest specificity (80.0%).

Our results of SelectMDx can be confirmed as significant but their impact on clinical practice together with a cost-effectiveness evaluation should be investigated in a larger prospective multicenter analysis.

World journal of urology. 2020 Jul 17 [Epub ahead of print]

Gian Maria Busetto, Francesco Del Giudice, Martina Maggi, Ferdinando De Marco, Angelo Porreca, Isabella Sperduti, Fabio Massimo Magliocca, Stefano Salciccia, Benjamin I Chung, Ettore De Berardinis, Alessandro Sciarra

Department of Urology, Sapienza Rome University, Policlinico Umberto I, Viale del Policlinico 155, 00161, Rome, Italy., Department of Urology, Sapienza Rome University, Policlinico Umberto I, Viale del Policlinico 155, 00161, Rome, Italy. ., I.N.I Istituto Neurotraumatologico Italiano-Urology Division-Grottaferrata, Grottaferrata, Rome, Italy., Department of Urology, Policlinico Abano Terme, Abano Terme, Italy., Biostatistical Unit-IRCCS, Regina Elena National Cancer Institute, Rome, Italy., Department of Radiological, Oncological and Anatomopathological Sciences, Sapienza Rome University, Policlinico Umberto I, Rome, Italy., Department of Urology, Stanford University Medical Center, Stanford, CA, USA.