To explore radiation oncologists' attitudes and practice patterns of radiotherapy for hormone-naïve prostate cancer with bone metastases in Japan.
An internet-based survey was distributed to board-certified radiation oncologists of the Japanese Society of Radiation Oncology. Three hypothetical cases were assumed: hormone-naïve prostate cancer with single, three or multiple non-symptomatic bone metastases. The respondents described their attitude regarding such cases, treatment methods and the radiotherapy dose fractionation that they would recommend.
Among the 1013 board-certified radiation oncologists in Japan, 373 (36.8%) responded to the questionnaire. Most of the respondents (85.0%) believed that radiotherapy may be applicable as a primary treatment for hormone-naïve prostate cancer with bone metastases in some circumstances. For Case 1 (single bone metastasis), 55.0% of the respondents recommended radiotherapy for the prostate and bone metastasis. For Case 2 (three bone metastases), only 24.4% recommended radiotherapy for all lesions, and 31.4% recommended radiotherapy for the prostate only. For Case 3 (multiple bone metastases), 49.1% of the respondents stated that there was no indication for radiotherapy. However, 34% of the respondents still preferred to administer radiotherapy for the prostate. The radiotherapy techniques and dose fractionations varied widely among the respondents.
Most of the respondent radiation oncologists believed that radiotherapy may be beneficial for hormone-naïve prostate cancer with bone metastases.
Japanese journal of clinical oncology. 2020 Jul 06 [Epub ahead of print]
Katsumasa Nakamura, Hitoshi Ishikawa, Tetsuo Akimoto, Manabu Aoki, Shinji Kariya, Hidemasa Kawamura, Tomoyasu Kumano, Takuyo Kozuka, Kenta Konishi, Masakuni Sakaguchi, Kenji Takayama, Other authors are shown in Appendix
Department of Radiation Oncology, Hamamatsu University School of Medicine, Hamamatsu, Japan., National Institutes for Quantum and Radiological Science and Technology, Hospital of the National Institute of Radiological Science, Chiba, Japan., Division of Radiation Oncology and Particle Therapy, National Cancer Center Hospital East, Chiba, Japan., Department of Radiology, Jikei University School of Medicine, Tokyo, Japan., Department of Radiology, Kochi Medical School, Nankoku, Japan., Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi, Japan., Department of Radiology, Gifu University of Medical Science, Graduate School of Medicine, Gifu, Japan., Department of Radiation Oncology, Toranomon Hospital, Tokyo, Japan., Department of Radiology, Nihon University School of Medicine, Tokyo, Japan., Department of Radiation Oncology, Tenri Yorozu Hospital, Tenri, Japan.