Genetic Association Analysis of Cell Cycle Regulators Reveals YWHAZ Has Prognostic Significance in Prostate Cancer.

This study aimed to identify the genes that cause biochemical recurrence (BCR) following radical prostatectomy (RP) in men with localized prostate cancer.

A two-stage genetic association study of 19 single-nucleotide polymorphisms in 11 key cell cycle regulation genes was carried out. BCR-free survival after RP was evaluated in a discovery cohort of 458 patients with prostate cancer, and replication was investigated in another cohort of 185 patients.

A consistent association was found between BCR and rs2290291 (discovery: p=0.008; replication: p=0.029). rs2290291 is located in the tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ), and was predicted to possess a regulatory function that affected YWHAZ expression. Furthermore, YWHAZ expression was frequently up-regulated in advanced tumours, and associated with poorer survival in patients with prostate cancer.

YWHAZ rs2290291 was found to be associated with BCR. YWHAZ may function as a putative oncogene during prostate cancer progression.

Cancer genomics & proteomics. 0000 Jan [Epub]

Chia-Cheng Yu, Lih-Chyang Chen, Wen-Hsin Lin, Victor C Lin, Chao-Yuan Huang, Te-Ling Lu, Cheng-Hsueh Lee, Shu-Pin Huang, Bo-Ying Bao

Division of Urology, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C., Department of Medicine, Mackay Medical College, New Taipei City, Taiwan, R.O.C., Department of Pharmacy, China Medical University, Taichung, Taiwan, R.O.C., Department of Urology, E-Da Hospital, Kaohsiung, Taiwan, R.O.C., Department of Urology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan, R.O.C., Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, R.O.C., Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, R.O.C. ., Department of Pharmacy, China Medical University, Taichung, Taiwan, R.O.C. .