Association between PSA density and prostate cancer in men without significant MRI lesions.

The 2019 European guidelines for prostate cancer recommend to omit biopsy when multiparametric magnetic resonance imaging (mpMRI) of the prostate shows no significant lesions (i.e. PI-RADS ≤2) and clinical suspicion of prostate cancer is low. However, it remains unclear how to define "low clinical suspicion" and one might assume, that clinical suspicion is usually more than low if a costly investigation such as MRI is ordered.

BJU international. 2020 Feb 28 [Epub ahead of print]

Ashkan Mortezavi, Martin Eklund, Martin Bergman, Svein R Kjosavik, Andrea Discacciati, Tobias Nordström

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden., The General Practice and Care Coordination Research Group, Stavanger University Hospital, Stavanger, Norway.