Risk of Postoperative Upstaging or Upgrading Among Men with Low-Risk Familial Prostate Cancer.

To investigate whether men with biopsy-verified low-grade cancer and a family history of lethal or advanced prostate cancer are at particularly high risk of harboring undetected high-grade disease.

Upgrading and upstaging of prostate cancer is common after prostatectomy. In a nationwide population-based cohort, we identified 6 854 men with low-risk prostate cancer who underwent radical prostatectomy. Among them, 1 739 (25%) had a history of prostate cancer among a first-degree relative, and 289 (4%) had a first degree relative with lethal or advanced prostate cancer.

Compared with men with no familial occurrence of prostate cancer, the odds ratio (OR) for the risk of upstaging among men with a familial occurrence of high-risk or lethal prostate cancer was 1.06 (95% CI, 0.76-1.47). The corresponding OR for upgrading was 1.17 (0.91-1.50).

We found no association between family history of prostate cancer and upstaging or upgrading after radical prostatectomy.

The Journal of urology. 2020 Jan 31 [Epub ahead of print]

Fredrik Jansson, Folke Folkvaljon, Pär Stattin, Ola Bratt, Olof Akre

Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden., Department of Surgical Sciences Uppsala University Hospital, Uppsala, Sweden., Deptarment of Urology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden.