Is There Still a Need for Repeated Systematic Biopsies in Patients with Previous Negative Biopsies in the Era of Magnetic Resonance Imaging-targeted Biopsies of the Prostate?

The role of targeted prostate biopsies (TBs) in patients with cancer suspicious lesions on multiparametric magnetic resonance imaging (mpMRI) following negative systematic biopsies (SBs) is undebated. However, whether they should be combined with repeated SBs remains unclear.

To evaluate the value of repeated SBs in addition to TBs in patients with a prior negative SB and a persistent suspicion of prostate cancer (PCa).

A prospective study as part of a multicenter randomized controlled trial conducted between 2014 and 2017, including 665 men with a prior negative SB and a persistent suspicion of PCa (suspicious digital rectal examination and/or prostate-specific antigen >4.0ng/ml).

All patients underwent 3T mpMRI according to Prostate Imaging Reporting and Data System (PI-RADS) v2. Patients with PI-RADS ≥3 were randomized 1:1:1 for three TB techniques: MRI-TRUS fusion TB (FUS-TB), cognitive registration fusion TB (COG-TB), or in-bore MRI TB. FUS-TB and COG-TB were combined with repeated SBs.

Clinically significant prostate cancer (csPCa) was defined as Gleason ≥3+4. Differences in detection rates of csPCa, clinically insignificant PCa (cisPCa), and overall PCa between TBs (FUS-TB and COG-TB) and repeated SBs were compared using McNemar's test.

In the 152 patients who underwent both TB and SB, PCa was detected by TB in 47% and by SB in 32% (p<0.001, 95% confidence interval [CI]: 6.0-22%). TB detected significantly more csPCa than SB (32% vs 16%; p<0.001, 95% CI: 11-25%). Clinically significant PCa was missed by TB in 1.3% (2/152). Combining SB and TB resulted in detection rate differences of 6.0% for PCa, 5.0% for cisPCa, and 1.0% for csPCa compared with TB alone.

In case of a persistent suspicion of PCa following a negative SB, TB detected significantly more csPCa cases than SB. The additional value of SB was limited, and only 1.3% of csPCa would have been missed when SB had been omitted.

We evaluated the role of systematic biopsies and magnetic resonance imaging (MRI)-targeted biopsies for the diagnosis of prostate cancer in patients with prior negative systematic biopsies. MRI-targeted biopsies perform better in detecting prostate cancer in these patients. The value of repeated systematic biopsies is limited.

European urology oncology. 2019 Jun 22 [Epub ahead of print]

Leonie Exterkate, Olivier Wegelin, Jelle O Barentsz, Marloes G van der Leest, J Alain Kummer, Willem Vreuls, Peter C de Bruin, J L H Ruud Bosch, Harm H E van Melick, Diederik M Somford

Department of Urology, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands. Electronic address: ., Department of Urology, St. Antonius Hospital, Nieuwegein/Utrecht, The Netherlands., Department of Radiology and Nuclear Medicine, Radboudumc Nijmegen, The Netherlands., Department of Pathology, St. Antonius Hospital, Nieuwegein/Utrecht, The Netherlands., Department of Pathology, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands., Department of Oncologic Urology, UMC, Utrecht, The Netherlands., Department of Urology, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.

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