In this review1, we discussed the progress of biomarker-driven prostate cancer molecular subtyping and the development of companion nanodiagnostic strategies to refine clinical biomarker detection. We also discussed the existing challenges of merging both aspects for precision prostate cancer management and provide insights into possible solutions.
We first covered novel prostate cancer-specific biomarkers (TMPRSS2–ETS fusion genes, PCA3, SChLAP1, PTEN, AR-V7) in blood and urine with better disease-informing abilities than PSA, as well as several existing biomarker-based diagnostic assays for supporting PSA screening outcomes that are available to clinicians. We then reviewed the emergence of nanotechnology-based approaches for miniaturized prostate cancer screening; including nanostructured materials, nanoparticles, and miniaturized integrated systems (Fig. 1). Lastly, we examined the current challenges in clinical translation of combined cutting-edge PCa biomarkers and nanodiagnostics: i) Validation of biomarker panels, ii) Clinical verification of nanodiagnostics, iii) Acceleration of validation processes, iv) Standardization of protocols, and v) Multidisciplinary collaboration.
All in all, we hope this Review bridges the knowledge gap between the prostate cancer clinical and nanodiagnostic research fields by informing clinicians about future possibilities and benefits of prostate cancer nanotechnology-based screening, and alerting nanotechnology researchers to the availability of next- generation prostate cancer biomarkers for integration into their nanodiagnostic research.
Kevin M. Koo1, Paul N. Mainwaring1*, Scott A. Tomlins2* and Matt Trau1, 3*
1Centre for Personalized Nanomedicine, Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Australia
2Department of Pathology, Department of Urology, Michigan Centre for Translational Pathology, Comprehensive Cancer Centre, University of Michigan, Ann Arbor, MI, USA
3School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Australia
- Koo, K. M.; Mainwaring, P. N.; Tomlins, S. A. & Trau, M. (2019) Merging new-age biomarkers and nanodiagnostic platforms for precision prostate cancer management. Rev. Urol. https://doi.org/10.1038/s41585-019-0178-2
- Koo, K. M.; Wee, E. J. H.; Wang, Y. & Trau, M. (2017) Enabling miniaturised personalised diagnostics: from lab- on-a-chip to lab- in-a- drop. Chip 17, 3200–3220.