Salvage lymph node dissection in patients with prostate cancer treated with radical prostatectomy or radiotherapy and positive choline positron emission tomography (PET/CT) scan.

Nodal prostate cancer recurrence is a challenging scenario. Current guidelines recommend the use of androgen deprivation therapy, tailored treatment or clinical trials. We studied the impact of Salvage lymph node dissection in selected patients.

We retrospectively reviewed records of 23 consecutive patients with prostate cancer and previous Radical prostatectomy or Radiotherapy who underwent SLND from December 2005 to November 2015.

We found that in patients that showed biochemical response the introduction of ADT was delayed 14.9 months compared to patients that did not responded (2.8 months) P=.00026. Furthermore although statistical significance was not reached (P=.072) PSA-DT could be a potential prognostic factor of radiological recurrence since patients with PSA-DT<6 months developed radiological recurrence 7.6 months earlier compared to their counterparts.

Salvage lymph node dissection is a potential treatment that could delay ADT in selected patients.

Actas urologicas espanolas. 2019 Apr 08 [Epub ahead of print]

R J Otta-Oshiro, F Lista-Mateos, J García-Mediero, J A Arranz-Arija, J García-Prado, C Núñez-Mora

Servicio de Urología, MD Anderson Cancer Center-Madrid, Madrid, España. Electronic address: ., Servicio de Urología, MD Anderson Cancer Center-Madrid, Madrid, España., Servicio de Oncología Médica, MD Anderson Cancer Center-Madrid, Madrid, España., Servicio de Radiodiagnóstico, MD Anderson Cancer Center-Madrid, Madrid, España.