A 3D-Printed Patient-Specific Phantom for External Beam Radiation Therapy of Prostate Cancer.

This paper presents the design evolution, fabrication, and testing of a novel patient and organ-specific, 3D printed phantom for external beam radiation therapy of prostate cancer. In contrast to those found in current practice, this phantom can be used to plan and validate treatment tailored to an individual patient. It contains a model of the prostate gland with a dominant intraprostatic lesion, seminal vesicles, urethra, ejaculatory duct, neurovascular bundles, rectal wall, and penile bulb generated from a series of combined T2-weighted/dynamic contrast-enhanced magnetic resonance images. The iterative process for designing the phantom based on user interaction and evaluation is described. Using the CyberKnife System at Boston Medical Center a treatment plan was successfully created and delivered. Dosage delivery results were validated through gamma index calculations based on radiochromic film measurements which yielded a 99.8% passing rate. This phantom is a demonstration of a methodology for incorporating high-contrast magnetic resonance imaging into computed-tomography-based radiotherapy treatment planning; moreover, it can be used to perform quality assurance.

Journal of engineering and science in medical diagnostics and therapy. 2018 Aug 06 [Epub]

Christopher L Lee, Max C Dietrich, Uma G Desai, Ankur Das, Suhong Yu, Hong F Xiang, C Carl Jaffe, Ariel E Hirsch, B Nicolas Bloch

Franklin W. Olin College of Engineering, 1000 Olin Way, Needham MA 02492., Department of Radiology Oncology, Boston Medical Center & Boston University School of Medicine, 820 Harrison Ave., Boston, MA 02118., Department of Radiology, Boston Medical Center & Boston University School of Medicine, 820 Harrison Ave., Boston, MA 02118.

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