Low Preoperative Prolactin Levels Predict Non-Organ Confined Prostate Cancer in Clinically Localized Disease.

To evaluate the association between preoperative serum prolactin (PRL) levels and risk of non-organ confined prostate cancer (PCa) in clinically localized disease.

From December 2007 to December 2011, 124 patients with clinically localized PCa were retrospectively evaluated. Non-organ confined disease in the surgical specimen was defined according to extra-capsular extension, seminal vesicle invasion, positive surgical margins, and lymph node invasion. The association between clinical factors and serum levels of pituitary-testis hormones with the risk of non-organ confined disease was evaluated.

Perioperative factors associated with non-organ confined disease include prostatic-specific antigen (OR 1.144; p = 0.025), proportion of biopsy positive cores (BPC, OR 36.702; p = 0.007), bioptical Gleason Score > 6 (OR 2.785; p = 0.034), and PRL (OR 0.756, p < 0.0001). The association was strong for BPC (area under the curve [AUC] 0.704; p < 0.0001) and PRL (AUC 0.299; p < 0.0001). When we dichotomized according to median value, PRL ≤7.7 µg/L was an independent predictor of extraprostatic disease (OR 6.571; p < 0.0001) with fair discrimination power (AUC 0.704; p < 0.0001).

Low preoperative PRL levels predict the risk of non-organ confined PCa in clinically localized disease.

Urologia internationalis. 2019 Feb 14 [Epub ahead of print]

Antonio Benito Porcaro, Alessandro Tafuri, Marco Sebben, Giovanni Cacciamani, Claudio Ghimenton, Matteo Brunelli, Aldo Petrozziello, Carmelo Monaco, Filippo Migliorini, Salvatore Siracusano, Walter Artibani

Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata Verona, Verona, ., Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy., Department of Pathology, University of Verona, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy., Department of Internal Medicine, Endocrinology Section, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.

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