To collect efficacy and safety data of enzalutamide after docetaxel, we retrospectively evaluated the Italian Named Patient Program results.
Two hundred and nine metastatic castration-resistant prostate cancer patients were enrolled. Median age was 73 years. Total 42.1% patients had pain, 14.4% had a performance status of two and 59.8% had a Gleason score ≥8. Total 31.1% had previously received ≥2 chemotherapies, 15.3 and 12% had been previously treated with abiraterone and cabazitaxel, respectively and 14.8% had received both.
Median progression-free survival and overall survival were 4.8 and 13.1 months, respectively. A prostate-specific antigen reduction ≥50% was observed in 49.1%. Total 32.7% abiraterone-pretreated patients achieved a biochemical response compared with 56% of abiraterone-naive patients.
Enzalutamide was safe and well tolerated. Its antitumor activity in abiraterone-pretreated patients was limited.
Future oncology (London, England). 2018 Sep 12 [Epub ahead of print]
Francesca Maines, Ugo De Giorgi, Giuseppe Procopio, Gaetano Facchini, Lucia Fratino, Roberto Sabbatini, Donatello Gasparro, Umberto Basso, Claudia Mosillo, Enrico Campadelli, Francesco Massari, Teodoro Sava, Suzana Sirotova, Caterina Messina, Sarah Scagliarini, Vincenza Conteduca, Elena Verzoni, Sabrina Rossetti, Antonello Veccia, Stefania Kinspergher, Orazio Caffo
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