Accurate validation of ultrasound imaging of prostate cancer: a review of challenges in registration of imaging and histopathology

As the development of modalities for prostate cancer (PCa) imaging advances, the challenge of accurate registration between images and histopathologic ground truth becomes more pressing. Localization of PCa, rather than detection, requires a pixel-to-pixel validation of imaging based on histopathology after radical prostatectomy. Such a registration procedure is challenging for ultrasound modalities; not only the deformations of the prostate after resection have to be taken into account, but also the deformation due to the employed transrectal probe and the mismatch in orientation between imaging planes and pathology slices. In this work, we review the latest techniques to facilitate accurate validation of PCa localization in ultrasound imaging studies and extrapolate a general strategy for implementation of a registration procedure.

Journal of ultrasound. 2018 Jul 30 [Epub ahead of print]

Rogier R Wildeboer, Ruud J G van Sloun, Arnoud W Postema, Christophe K Mannaerts, Maudy Gayet, Harrie P Beerlage, Hessel Wijkstra, Massimo Mischi

Laboratory of Biomedical Diagnostics, Department of Electrical Engineering, Eindhoven University of Technology, De Rondom 70, 5612 AP, Eindhoven, The Netherlands. ., Laboratory of Biomedical Diagnostics, Department of Electrical Engineering, Eindhoven University of Technology, De Rondom 70, 5612 AP, Eindhoven, The Netherlands., Department of Urology, Academic Medical Center University Hospital, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands., Department of Urology, Jeroen Bosch Hospital, Henri Dunantstraat 1, 5223 GZ, 'S-Hertogenbosch, The Netherlands.

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