Younger Men with Prostate Cancer have Lower Risk of Upgrading while on Active Surveillance: A Meta-analysis and Systematic Review of the Literature

Active surveillance (AS) has become a popular option for patients with low risk prostate cancer. Our objective was to examine the correlation between age and the risk of Gleason upgrading and biopsy progression. A systematic search was conducted. Eight studies met our eligibility criteria including 6,522 patients with median age of 65.8 (41-86) years. Per decade decrease in age, the pooled OR and HR (CI 95%) for Gleason upgrading were 0.83 (0.73-0.94) and 0.87 (0.82-0.92), and for biopsy progression were 0.80 (0.74-0.86) and 0.88 (0.79-0.99), respectively. Overall, younger patients have a lower risk of GS upgrading and biopsy progression.

Urology. 2018 Jul 26 [Epub ahead of print]

Amr Mahran, Andrew Turk, Christina Buzzy, Michael Wang, Julia Yang, Mandy Neudecker, Irina Jaeger, Lee E Ponsky

Division of Urologic Oncology, Urology Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA; Case Western Reserve University School of Medicine, Cleveland, Ohio, USA; Department of Urology, Assiut University, Egypt., Division of Urologic Oncology, Urology Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA., Division of Urologic Oncology, Urology Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA; Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Core Library, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA., Division of Urologic Oncology, Urology Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA; Case Western Reserve University School of Medicine, Cleveland, Ohio, USA. Electronic address: .

E-Newsletters

Newsletter subscription

Free Daily and Weekly newsletters offered by content of interest

The fields of GU Oncology and Urology are rapidly advancing. Sign up today for articles, videos, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.

Subscribe