High expression of several androgen receptor coactivators is frequently reported in prostate cancer. Coactivators such as p300/CBP are involved in modulation of androgen receptor activity by increasing the effects of androgenic hormones and enhancing agonistic activity of antiandrogens. Studies in the field of prostate cancer frequently examined the role of p300/CBP and SRC-1 (NCOA1). In addition to their effects on steroid receptor activity, coactivators may influence other cellular functions such as migration and invasion. Steroid receptor coactivators may target various downstream genes, thus modulating proliferative and migratory responses in specific prostate cancer models. This chapter will focus on methodologies used to analyze the role of steroid receptor coactivators in prostate cancer.
Methods in molecular biology (Clifton, N.J.). 2018 Jan [Epub]
Zoran Culig, Frédéric R Santer
Experimental Urology, Department of Urology, Medical University of Innsbruck, Innsbruck, Austria. ., Experimental Urology, Department of Urology, Medical University of Innsbruck, Innsbruck, Austria.