[Salvage cryotherapy of prostate cancer after failed external radiotherapy and brachytherapy: Morbidity and mid-term oncological results]

To study the oncologic and functional results of salvage cryotherapy after failure of external radiotherapy and brachytherapy.

Patients treated by total salvage cryotherapy (3rd generation) in 2 centers (Groupe Hospitalier Saint-Joseph in Paris and Clinique Jule-Verne Nantes) in between January 2008 and April 2016 were included. The biochemical recurrence-free survival (BRFS) was calculated using the Phoenix criteria (PSA>nadir+2ng/mL). The functional results were assessed clinically.

Ninety-seven patients with an average follow up of 39.4months were evaluated retrospectively. The 5-year biochemical recurrence-free survival (5y-BRFS) among all patients was 58.1% (IC à 95% [45.9-68.5]). Low and intermediate risk patients (d'Amico classification) were less prone to biochemical recurrence than high risk (81.05% (IC à 95% [64.1-90.5]) 5y-BRFS as opposed to 35.09% (IC à 95% [20.1-50.4]) respectively) (P<0.0001). As were patients with a Gleason score≤7 75.35% (IC à 95% [59.7-85.6]) compared to 32.31% (IC à 95% [16.5-49.2]) for higher Gleason (>7 scores [P=0.0002]). A Gleason score>7 (OR=6.9; P=0.002), PSA nadir>1ng/mL (OR=25.8; P=0.0026) and peri-urethral invasion (OR=35.8; P<0.001) were major risk factors for local recurrence in univariate analysis. In multivariate analysis, only PSA nadir>1ng/mL (OR=12.9; P=0.042) and peri-urethral invasion (OR=21.6; P=0.0003) remain major risk factors for recurrence. About 13 (16.46%) patients were incontinent of which 3 (3.79%) required placement of an artificial urinary sphincter. Erectile dysfunction was present in 66 (83.5%) patients. Recto-urethral fistula was uncommon in 1 patient (1.27%).

Salvage cryotherapy after failure of external radiotherapy and brachytherapy is a reliable and reproducible technique with promising oncological and functional results. Study of prognostic factors will help better select eligible patients in the future.

4.

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie. 2018 Mar 16 [Epub]

A Gevorgyan, J-F Hétet, M Robert, V Duchattelle-Dussaule, L Corno, I Boulay, H Baumert

Service d'urologie, CHRU Lapeyronie, 191, avenue du Doyen-Gaston-Giraud, 34090 Montpellier, France. Electronic address: ., Service de chirurgie urologique, clinique Jules-Verne, 2-4, route de Paris, 44314 Nantes cedex 3, France., Service d'urologie, CHRU Lapeyronie, 191, avenue du Doyen-Gaston-Giraud, 34090 Montpellier, France., Service d'urologie, CHRU Lapeyronie, 191, avenue du Doyen-Gaston-Giraud, 34090 Montpellier, France; Service de chirurgie urologique, clinique Jules-Verne, 2-4, route de Paris, 44314 Nantes cedex 3, France; Service d'urologie, groupe hospitalier Paris Saint-Joseph, 18, rue Raymond-Losserand, 75674 Paris cedex 14, France., Service d'urologie, groupe hospitalier Paris Saint-Joseph, 18, rue Raymond-Losserand, 75674 Paris cedex 14, France.

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