Aspirin has cyclooxygenase-2 (COX2)-mediated anti-inflammatory and anti-coagulant properties that may confer a positive effect in preventing and limiting the progression of prostate cancer. Prostate cancer has been shown to have poor treatment outcomes due to therapeutic resistance; therefore, COX2 inhibition caused by aspirin could represent an opportunity to augment current therapies. This is particularly of interest to patients undergoing radiation therapy (RT) where inflammation is a common side-effect. This review discusses the evidence for the potential role of aspirin in the management of patients with prostate cancer undergoing RT.
Anticancer research. 2018 Apr [Epub]
Bianca Mascan, Laure Marignol
Applied Radiation Therapy Trinity, Discipline of Radiation therapy, Trinity College, Dublin, Ireland., Applied Radiation Therapy Trinity, Discipline of Radiation therapy, Trinity College, Dublin, Ireland .