Dynamic Sentinel Lymph Node Biopsy for Penile Cancer: A Comparison between One and Two-day Protocols

To determine the outcome of clinically negative node (cN0) patients with penile cancer undergoing Dynamic Sentinel Node Biopsy (DSNB), comparing the results of a one and two day protocol that can be used as a minimal invasive procedure for staging of penile cancer.

This is a retrospective analysis of 151 cN0 patients who underwent DSNB from 2008-2013 for newly diagnosed penile cancer. Data were analyzed per groin and separated into groups according to the protocol followed. The comparison of the two protocols involved the number of nodes excised, gamma counts, false negative rate and complication rate (Clavien-Dindo grading system (CD)).

280 groins from 151 patients underwent DSNB following a negative USS±FNAC (Ultrasound ± Fine Needle Aspiration Cytology). One-day protocol was performed in 65 groins and two-day protocol in 215. A statistically significant higher number of nodes were harvested with the one-day protocol (1. 92/groin) compared to the two-day protocol (1. 60/groin). The false negative rates were 0%, 6. 8% and 5. 1%. for one day and two day protocols, and overall respectively. Morbidity of the DSNB was 21. 4% for all groins and 26. 2% and 20. 1% for one day and two day protocols respectively. The majority of the complications were of CD grade 1-2.

DSNB is safe for staging penile cancer patients. There is a trend towards a one day protocol having a lower false negative rate than a two day protocol, albeit at the expense of a slightly higher complication rate. This article is protected by copyright. All rights reserved.

BJU international. 2015 Dec 08 [Epub ahead of print]

Panagiotis Dimopoulos, Panagiotis Christopoulos, Sam Shilito, Zara Gall, Brian Murby, David Ashworth, Ben Taylor, Bernadette Carrington, Jonathan Shanks, Noel Clarke, Vijay Ramani, Nigel Parr, Maurice Lau, Vijay Sangar

Department of Urology, The Christie Hospital Manchester, UK. , Department of Urology, The Christie Hospital Manchester, UK. , Medical School, University Of Manchester, UK. , Department of Urology, The Christie Hospital Manchester, UK. , Nuclear Medicine Department, The Christie Hospital Manchester, UK. , Nuclear Medicine Department, The Christie Hospital Manchester, UK. , Department of Radiology, The Christie Hospital Manchester, UK. , Department of Radiology, The Christie Hospital Manchester, UK. , Department of Pathology, The Christie Hospital Manchester, UK. , Department of Urology, The Christie Hospital Manchester, UK. , Department of Urology, The Christie Hospital Manchester, UK. , Department of Urology, The Christie Hospital Manchester, UK. , Department of Urology, The Christie Hospital Manchester, UK. , Department of Urology, The Christie Hospital Manchester, UK.

PubMed

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