Real World Data of Penile Cancer Treatment at a High-Volume Center in South America: Insights and Survival Trends.

To report survival trends and oncological outcomes of penile cancer surgically treated patients, at a high-volume center, treating more than 25 patients each year, in a high incidence country.

Clinical charts of all patients that underwent surgical management for PC were reviewed. The primary end points were cancer specific survival (CSS), progression-free survival (PFS), and local recurrence free survival (L-RFS). Kaplan-Meier plots were used for survival analyses. Multivariate analysis was performed using cox proportional hazard age-adjusted models to determine the effect of pN, pT, lymphovascular invasion (LVI) for CSS.

209 patients were identified, with a median follow up of 96 months (IQR 49-133). Organ-sparing surgery (OSS) was performed in 72.7%, 56.9% underwent dynamic sentinel lymph node biopsy (DSLNB), 110 patients underwent inguinal lymph node dissection, and 45 (21.5%) pelvic lymph node dissection. A total of 75 (35.8%) of patients relapsed, median time to relapse of 12 months (IQR 6-25). Overall estimates of CSS showed an 8-year CSS of 68.9%. 8-year CSS was 90.5% for N0, and 32.8% in pN3 (p <0.001).The Cox proportional hazard model showed that pN1-3, pT2-4, LVI and positive DSLNB were the variables associated with worse 8-year CSS.

To the best of our knowledge, we report one of the largest cohorts on the survival outcomes of PC surgical treatment, in a single institution, over a long period of time, were most patients are referred with High-risk, locally advanced or nodal disease.

Urology. 2021 Jul 23 [Epub ahead of print]

Julián Chavarriaga, Julián Pardo, Daniel Suso-Palau, Luis Becerra, Diego Camacho, Fabián Godoy, Jorge Forero, Marino Cabrera, Byron López-de-Mesa, Angie Ramirez, Rodolfo Varela

Department of Urologic Oncology, Instituto Nacional de Cancerología. Bogotá, Colombia. Carrera 1 # 9-85; Division of Urology, Clínica Imbanaco, Grupo Quirón Salud. Cali, Colombia; Division of Urology, Pontificia Universidad Javeriana. Bogotá, Colombia. Electronic address: ., Department of Urologic Oncology, Instituto Nacional de Cancerología. Bogotá, Colombia. Carrera 1 # 9-85., Division of Urology, Clínica Imbanaco, Grupo Quirón Salud. Cali, Colombia.