Penile cancer with positive nodes: A case of HPV p16-positivity and its significance, implication of data from head and neck cancer.

Penile cancer is normally discovered in an early stage due to its visibility to the patient. This case report demonstrates a morbidly obese patient with a locally advanced penile cancer hidden by fatty tissue. Biopsy showed P16-positive tumor cells, which responded to concurrent chemo-radiotherapy with no evidence of disease at 24 months of follow-up. We also review the significance of p16-positive cell biology.

Urology case reports. 2019 Sep 04*** epublish ***

Cam Nguyen, Stephen Leslie, John Gross, Nicholas Dietz, Subodh M Lele, Gopi Sirineni

Division of Radiation Oncology, Creighton University Medical Center, Omaha, NE, USA., Department of Urology, Creighton University School of Medicine, Omaha, NE, USA., Department of Pathology, Creighton University Medical Center, Omaha, NE, USA., Department of Pathology, University of Nebraska Medical Center, Omaha, NE, USA., Department of Radiology, Creighton University Medical Center, Omaha, NE, USA.

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